What is Preimplantation Genetic Diagnosis (PGD) and can PGD increase the chances of pregnancy through in-vitro fertilization (IVF)?

PGD is a genetic testing of the chromosomes of the embryos; it's performed on one or two cells taken from a live early stage embryo created by in-vitro fertilization. The procedure is usually performed to remove genetically defective human embryos before they are transferred into the womb of the woman.

PGD allows the embryologist to choose only the healthiest embryos; and therefore fewer, for transfer. This refined selection process facilitates an increased chance of implantation, pregnancy and a healthy live birth. The opportunity of reducing multiple pregnancies is more attainable with PGD.

Good candidates for PGD are:
" Couples who are concerned about passing a genetically based disease to their offspring

" When both partners are over 35 years old

" Couples wanting to balance their family (gender selection)

" History of recurrent miscarriage

" Repeated IVF failure

Rifaat Salem, M.D., Ph.D.
Diplomate, American Board of Obstetrics and Gynecology
Member, South Bay Independent Physicians Medical Group, Inc.